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|Title:||Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?|
|Authors:||Whiteman, M. |
|Source:||Whiteman, M., Halliwell, B., Rose, P. (2003). Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?. Biochemical and Biophysical Research Communications 303 (4) : 1217-1224. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-291X(03)00503-5|
|Abstract:||Acute and chronic inflammation result in increased nitrogen monoxide (̇NO) formation and the accumulation of nitrite (NO2-). Neutrophils stimulated by various inflammatory mediators release myeloperoxidase to produce the cytotoxic agent hypochlorous acid (HOCl). At physiologically attainable concentrations, we found that NO2- significantly inhibits HOCl-mediated DNA strand breakage and ascorbate depletion. HOCl-mediated inactivation of pure α1-antiproteinase or of the elastase inhibitory capacity of human plasma was inhibited by the addition of NO2-. NO2- was more effective than ascorbate, GSH, and urate at inhibiting HOCl-mediated toxicity to human HepG2 cells in culture. These data suggest that NO2- may act in an antioxidant manner by removing HOCl at sites of inflammation where both HOCl and ̇NO are overproduced. © 2003 Elsevier Science (USA). All rights reserved.|
|Source Title:||Biochemical and Biophysical Research Communications|
|Appears in Collections:||Staff Publications|
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