Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-1097(03)00100-9
Title: Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity
Authors: Ding, W.-X.
Ong, C.N. 
Keywords: Apoptosis
Hepatotoxicity
Microcystin
Reactive oxygen species
Issue Date: 2003
Citation: Ding, W.-X., Ong, C.N. (2003). Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiology Letters 220 (1) : 1-7. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1097(03)00100-9
Abstract: Microcystins produced by cyanobacteria are potent and specific hepatotoxins; however, the mechanisms of microcystin-induced hepatotoxicity have not been fully elucidated. The induction of free radical formation and mitochondrial alterations are two major events found in microcystin-treated cultured rat hepatocytes. The mitochondrial alterations, i.e. loss of mitochondrial membrane potential and mitochondria permeability transition are now recognized as key steps in apoptosis. The activation of calpain and Ca2+/calmodulin-dependent protein kinase II is believed to be critical in the microcystin-induced apoptotic process. © 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Source Title: FEMS Microbiology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/31929
ISSN: 03781097
DOI: 10.1016/S0378-1097(03)00100-9
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