Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0027-5107(97)00151-6
Title: Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?
Authors: Ni, Z.-Y.
Liu, Y.-Q.
Shen, H.-M. 
Chia, S.E. 
Ong, C.N. 
Keywords: 8-Hydroxydeoxyguanosine
DNA adduct
Oxidation
Semen
Sperm
Issue Date: 1997
Source: Ni, Z.-Y., Liu, Y.-Q., Shen, H.-M., Chia, S.E., Ong, C.N. (1997). Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 381 (1) : 77-82. ScholarBank@NUS Repository. https://doi.org/10.1016/S0027-5107(97)00151-6
Abstract: Several studies have suggested a population-wide decline in the quality of human semen during the past three decades, but the mechanism remains unclear. It was proved that damage to the DNA of germ cells would lead to mutation, and 8-hydroxydeoxyguanosine (8-OHdG), one of the major products of oxidative damage to DNA, may serve as one of the important factors to affect the sperm quality. In the present paper, 67 semen samples were collected to analyze the sperm quality (density, sperm number, motility, normal head, etc.), and 8-OHdG was measured in DNA isolated from the same sperm samples. The results showed that a significantly inverse correlation exists between 8-OHdG/dG(deoxyguanosine) and sperm density (r = -0.358, p = 0.004), and between 8-OHdG/dG and sperm number (r = - 0.389, p = 0.01). The results indicate that endogenous oxidative DNA damage could affect sperm quality and subsequently increase the risk of genetic defects.
Source Title: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/31891
ISSN: 00275107
DOI: 10.1016/S0027-5107(97)00151-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

32
checked on Feb 27, 2018

WEB OF SCIENCETM
Citations

29
checked on Feb 19, 2018

Page view(s)

108
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.