Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-8741(96)01471-7
Title: In vitro response of Blastocystis hominis against traditional Chinese medicine
Authors: Yang, L.Q.
Singh, M. 
Yap, E.H. 
Ng, G.C.
Xu, H.X.
Sim, K.Y. 
Keywords: Blastocystis hominis
Drug response
Traditional medicine
Issue Date: 1996
Source: Yang, L.Q.,Singh, M.,Yap, E.H.,Ng, G.C.,Xu, H.X.,Sim, K.Y. (1996). In vitro response of Blastocystis hominis against traditional Chinese medicine. Journal of Ethnopharmacology 55 (1) : 35-42. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-8741(96)01471-7
Abstract: This is the first in vitro study on the activity of 20 kinds of crude extracts of traditional Chinese medicine (TCM) on the intestinal parasite, Blastocystis hominis using the criteria of living cell count (LCC) and living cell rate (LCR). LCC and LCR were applied as observation indicators, the former as a fixed-quantity and the latter as a fixed-quality method. LCR calculated percentage rate of living cells using eosin-brilliant cresyl blue staining which could differentiate between living cells and dying or dead cells. There were five extracts with no inhibitory activity, thirteen with moderate inhibition and two with high inhibition. The crude extracts of Coptis chinensis (CC) and Brucea javanica (BJ) were found to be most active against B. hominis. The active concentration of CC was 100 μg/ml. The active concentration of BJ was 500 μg/ml. The active concentration of metronidazole (MD) was 10 μg/ml and this was taken as an active standard drug for B. hominis.
Source Title: Journal of Ethnopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/31509
ISSN: 03788741
DOI: 10.1016/S0378-8741(96)01471-7
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