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Title: The pathology of systemic iridoviral disease in fish
Authors: Gibson-Kueh, S.
Ngoh-Lim, G.H.
Chang, S.F.
Ho, L.L.
Netto, P.
Qin, Q.W. 
Chua, F.H.C.
Ng, M.L. 
Ferguson, H.W.
Keywords: Fish
Lymphocystis diseae
Systemic iridoviral disease
Viral infection
Issue Date: 2003
Citation: Gibson-Kueh, S., Ngoh-Lim, G.H., Chang, S.F., Ho, L.L., Netto, P., Qin, Q.W., Chua, F.H.C., Ng, M.L., Ferguson, H.W. (2003). The pathology of systemic iridoviral disease in fish. Journal of Comparative Pathology 129 (2-3) : 111-119. ScholarBank@NUS Repository.
Abstract: Iridoviruses have been associated with severe disease and economic loss in farmed food fish and ornamental fish, with mortality often reported to reach 50% or more. In the present study, three tropical marine food fish species and four tropical freshwater ornamental fish species with systemic iridovirus infections were examined histopathologically and ultrastructurally. Light microscopy consistently revealed pale to intensely basophilic hypertrophied virus-infected cells in spleen, kidney and intestine from all seven species. Ultrastructural examination showed changes in the vascular endothelium overlying hypertrophied virus-infected cells suggestive of pressure necrosis. Viral isolation was improved by the use of fibroblastic cell lines. This, together with the sub-endothelial location of infected cells in all infected species examined, suggests that systemic iridoviruses are mesotheliotropic. © 2003 Elsevier Ltd. All rights reserved.
Source Title: Journal of Comparative Pathology
ISSN: 00219975
DOI: 10.1016/S0021-9975(03)00010-0
Appears in Collections:Staff Publications

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