Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0889-8553(05)70152-7
Title: Accurate diagnosis of Helicobacter pylori: Serologic testing
Authors: Ho, B. 
Marshall, B.J.
Issue Date: 2000
Source: Ho, B., Marshall, B.J. (2000). Accurate diagnosis of Helicobacter pylori: Serologic testing. Gastroenterology Clinics of North America 29 (4) : 853-862. ScholarBank@NUS Repository. https://doi.org/10.1016/S0889-8553(05)70152-7
Abstract: Serologic testing is a useful noninvasive testing strategy for H. pylori. It is particularly useful in areas where the prevalence of H. pylori is high and inexpensive point-of-contact fingerprick tests are used. Sensitive tests are valuable ways of excluding H. pylori infection and can be used in conjunction with a direct test (urease histology culture or breath test) to confirm absence of H. pylori if the two methods are concordant. Serologic testing is more definitive and differentiating if the antigenic epitopes of H. pylori can be differentiated based on the antigenic epitopes that specifically associate with gastric cancer, peptic ulcer, and nonulcer dyspepsia. A study by Kawahara's group22 reported that Hsp 60 may be involved in the development of mucosa-associated lymphoid tissue based on ELISA. The idea of differentiating antigens for H. pylori may open a new area for use of serologic testing in the diagnostic approach of H. pylori infections.
Source Title: Gastroenterology Clinics of North America
URI: http://scholarbank.nus.edu.sg/handle/10635/31371
ISSN: 08898553
DOI: 10.1016/S0889-8553(05)70152-7
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