Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0165-2427(02)00077-6
Title: Neuroendocrine-immune interactions in fish: A role for interleukin-1
Authors: Engelsma, M.Y.
Huising, M.O.
Van, Muiswinkel W.B.
Savelkoul, H.F.J.
Verburg-Van, Kemenade B.M.L.|Flik, G.
Kwang, J. 
Keywords: Cortisol
Cytokines
Fish
Glucocorticoids
HPA
HPI
Interleukin-1
Review
Issue Date: 2002
Source: Engelsma, M.Y., Huising, M.O., Van, Muiswinkel W.B., Savelkoul, H.F.J., Verburg-Van, Kemenade B.M.L.|Flik, G., Kwang, J. (2002). Neuroendocrine-immune interactions in fish: A role for interleukin-1. Veterinary Immunology and Immunopathology 87 (3-4) : 467-479. ScholarBank@NUS Repository. https://doi.org/10.1016/S0165-2427(02)00077-6
Abstract: Bi-directional communication between the hypothalamus-pituitary-adrenal (HPA)-axis and the sympathetic nervous system with the immune system is crucial to ensure homeostasis. Shared use of ligands and especially receptors forms a key component of this bi-directional interaction. Glucocorticoids (GC), the major end products of the HPA-axis differentially modulate immune function. Cytokines, especially interleukin-1 (IL-1), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), ensure immune signalling to the neuroendocrine system. In addition, hormones from leukocyte origin such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and β-endorphin, as well as centrally synthesised and secreted cytokines, contribute to the communication network. In teleost fish cortisol is the major product of the hypothalamus-pituitary-interrenal (HPI)-axis which is the teleost equivalent of the HPA-axis. Moderate and substantial increases in cortisol during stressful circumstances negatively affect B-lymphocytes, whereas rescue of neutrophilic granulocytes may support innate immunity. Recent elucidation of lower vertebrate cytokine sequences has facilitated research into neuroendocrine-immune interactions in teleosts and the first evidence for a significant function of interleukin-1 in the bi-directional communication is discussed. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: Veterinary Immunology and Immunopathology
URI: http://scholarbank.nus.edu.sg/handle/10635/31324
ISSN: 01652427
DOI: 10.1016/S0165-2427(02)00077-6
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