Please use this identifier to cite or link to this item:
|Title:||Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung|
|Authors:||Inglis, T.J.J. |
|Citation:||Inglis, T.J.J., Sherratt, M.J., Sproat, L.J., Gibson, J.S., Hawkey, P.M. (1993). Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung. Lancet 341 (8850) : 911-913. ScholarBank@NUS Repository. https://doi.org/10.1016/0140-6736(93)91208-4|
|Abstract:||The source of ventilator-associated pneumonia (gastric or oropharyngeal flora) remains controversial. We investigated the source of bacterial colonisation of the ventilated lung in 100 consecutive intensive-care patients. Gram-negative bacilli were isolated from the lower respiratory tract in 19 patients. Bacteria isolated from the stomach contents either previously or at the same time were identical to lower respiratory isolates in 11 patients. No gram-negative oropharyngeal isolate was identical to a lower respiratory tract isolate. Gastric bacterial overgrowth with gram-negative bacilli was associated with the presence of bilirubin in the stomach contents. Detectable bilirubin was also associated with subsequent acquisition of gram-negative bacilli in the lower respiratory tract. Only 5 gastric aspirate specimens with pH <3.5 contained gram-negative bacilli. These results establish a relation between duodenal reflux and subsequent bacterial colonisation of the lower respiratory tract. Restoration of normal gastroduodenal motility might help prevent pneumonia in intensive-care patients.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 14, 2018
WEB OF SCIENCETM
checked on Nov 6, 2018
checked on Oct 13, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.