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|Title:||Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels|
|Authors:||Taylor, M.B. |
Sub-minimum inhibitory concentration
|Source:||Taylor, M.B., Oh, J.H.L., Kang, K.L., Chow, V.T.K. (2005). Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels. FEMS Microbiology Letters 243 (2) : 379-384. ScholarBank@NUS Repository.|
|Abstract:||Intermedilysin is a cytolytic toxin produced by Streptococcus intermedius, a pathogen of humans. In vitro studies showed that exposure of S. intermedius to sub-minimum inhibitory concentration (MIC) levels (1/2 MIC) of protein-inhibiting antibiotics and nucleic acid-inhibiting antibiotics decreased intermedilysin release by S. intermedius. The most potent antibiotic was clindamycin. On the other hand, exposure to cell wall-inhibiting antibiotics generally showed insignificant changes in intermedilysin release at sub-MIC concentrations. Investigations into possible mechanisms underlying this sub-MIC effect with clindamycin showed that there was selective decrease in biosynthesis and release of toxin after exposure to 1/2 MIC condition. However, no significant differences in the mRNA levels of the intermedilysin gene were observed. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.|
|Source Title:||FEMS Microbiology Letters|
|Appears in Collections:||Staff Publications|
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