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|Title:||Helicobacter pylori in familial clusters based on antibody profile|
|Source:||Ng, B.L.,Ng, H.C.,Ho, B.,Goh, K.T. (2001). Helicobacter pylori in familial clusters based on antibody profile. FEMS Immunology and Medical Microbiology 30 (2) : 139-142. ScholarBank@NUS Repository. https://doi.org/10.1016/S0928-8244(00)00242-X|
|Abstract:||Studies have shown a high prevalence of Helicobacter pylori infection in close communities and that intrafamilial spread during early childhood may be a route of transmission. A total of 72 household members from 21 families were enrolled in this study. Sera from individuals showed 50/72 (69.4%) seropositive for IgG against H. pylori by ELISA. Western blots showed diversity in the protein profiles with molecular masses ranging from ∼8 to 130 kDa. Cohen's κ statistical analysis of the blot patterns showed that nine families demonstrated similar profiles (100%), while 4 other families showed varying similarities (17-50%). The results support the hypothesis of intrafamilial transmission of H. pylori. Furthermore, serological studies can be used as an effective approach to determine the familial status in relation to H. pylori infection. © 2001 Federation of European Microbiological Societies.|
|Source Title:||FEMS Immunology and Medical Microbiology|
|Appears in Collections:||Staff Publications|
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