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Title: Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori-infected BALB/c mice
Authors: Liu, B.H.
Lee, Y.K. 
Keywords: BALB/c mice
Helicobacter pylori
Reactive free oxygen metabolites (ROMs)
Secondary carotenoids (SC)
T helper type 1 (Th1), T helper type 2 (Th2)
Issue Date: 2003
Source: Liu, B.H., Lee, Y.K. (2003). Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori-infected BALB/c mice. International Immunopharmacology 3 (7) : 979-986. ScholarBank@NUS Repository.
Abstract: Helicobacter pylori is a human pathogen associated with type B gastritis, peptic ulcer disease and gastric cancer. A high intake of carotenoids has been suggested to prevent development of gastric malignancies. Microalgae Chlorococcum sp. could accumulate secondary carotenoids under stress conditions. The aim of the present study was to investigate whether dietary cell extract of Chlorococcum sp. could affect the bacterial load of H. pylori infected BALB/c mice and whether it could induce modulation of cytokine production. BALB/c mice were infected with H. pylori three times at 2-day intervals. Two weeks later, they were orally fed with cell extract of Chlorococcum sp. for the following 2 weeks. Animals were killed at the end of the experiments. Stomachs were removed and paraffin sections were stained for histology examination. Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-γ) and interleukin 4 (IL-4) secretion. Mice treated with carotenoids-rich algal meal showed significantly reduced bacterial load and gastric inflammation. These changes were associated with a shift of the T-lymphocytes response from a predominant T helper type 1 (Th1) response dominated by IFN-γ to a Th1/Th2 response with IFN-γ and IL-4. © 2003 Elsevier Science B.V. All rights reserved.
Source Title: International Immunopharmacology
ISSN: 15675769
DOI: 10.1016/S1567-5769(03)00096-1
Appears in Collections:Staff Publications

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