Please use this identifier to cite or link to this item:
Title: Immunodominance and immunoprotection of anti-viral specific CD8+ T cell response during HBV infection
Keywords: HBV, T cell, HLA, Hepatic flares, CXCL9, CXCL10
Issue Date: 1-Aug-2011
Citation: TAN ANTHONY TANOTO (2011-08-01). Immunodominance and immunoprotection of anti-viral specific CD8+ T cell response during HBV infection. ScholarBank@NUS Repository.
Abstract: This thesis focuses on two aspects of T cell responses during HBV infection, namely: 1) the factors that influence the immunodominant hierarchy of HBV-specific T cells and 2) immunoprotection of HBV-specific T cells during hepatic flares. In chapter 1, I analyzed the impact that host and virus variables exert on repertoire composition, quantity and qualitative functional ability of virus-specific T cells. I demonstrate that HBV-specific T cell quantity is largely determined by the virological and clinical profile of the patients, while the repertoire is shaped by the HLA-haplotype of the host. In chapter 2, I longitudinally studied the kinetics of immune activation during hepatic flares (HF) in chronic hepatitis B to determine whether HBV replication rebound and HF are associated with the activation of innate or adaptive immunological events or the recovery of HBV-specific immunity. I observed that both HBV replication rebound and HF were not associated with a recovery of peripheral HBV-specific T cell immunity. Instead, HF were strongly associated with elevated serum levels of CXCL-9 and CXCL-10, suggesting the occurrence of non-specific hepatic recruitment of T cells that could mediate the liver pathology.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TanAT.pdf8.69 MBAdobe PDF



Page view(s)

checked on Dec 8, 2018


checked on Dec 8, 2018

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.