Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/30546
Title: A STUDY OF PARTICLE ENGINEERING AND AEROSOLIZATION IN DRY POWDER INHALERS
Authors: KOU XIANG
Keywords: dry powder inhaler, particle engineering, aerosolization visulization, PIV, image analysis, mechanism study
Issue Date: 5-Aug-2011
Source: KOU XIANG (2011-08-05). A STUDY OF PARTICLE ENGINEERING AND AEROSOLIZATION IN DRY POWDER INHALERS. ScholarBank@NUS Repository.
Abstract: This project aimed to investigate various methods of producing dry powder inhaler particles and to study the particle aerosolization process in the inhaler device chamber. Conventional methods, such as sieving, classifying, classifying milling and spray drying, and new methods, such as pin milling, jet milling and roller compaction, were employed to produce coarse carrier particles. The jet milled coarse carrier particles produced were found to possess a unique shape that enabled better drug deposition to the target site. Jet milling roller compacted lactose produced superior coarse carrier particles due to roughened surfaces. Particle dispersion mechanism was elucidated by employing particle image velocimetry (PIV) technique. Conditions that facilitated particle impacts and collisions were beneficial for detachment of fine particles for delivery to the target site. A collision hypothesis was proposed for the dispersive mechanism of fines from coarse carriers.
URI: http://scholarbank.nus.edu.sg/handle/10635/30546
Appears in Collections:Ph.D Theses (Open)

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