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https://doi.org/10.1016/j.transproceed.2004.11.057
DC Field | Value | |
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dc.title | Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats | |
dc.contributor.author | Wang, D.Z. | |
dc.contributor.author | Khoo, A. | |
dc.contributor.author | Calne, R. | |
dc.contributor.author | Isaac, J.R. | |
dc.contributor.author | Lee, K.O. | |
dc.contributor.author | Salto-Tellez, M. | |
dc.contributor.author | Skinner, S. | |
dc.contributor.author | Elliot, R. | |
dc.contributor.author | Garkavenko, O. | |
dc.contributor.author | Escobar, L. | |
dc.date.accessioned | 2012-02-01T09:15:55Z | |
dc.date.available | 2012-02-01T09:15:55Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Wang, D.Z., Khoo, A., Calne, R., Isaac, J.R., Lee, K.O., Salto-Tellez, M., Skinner, S., Elliot, R., Garkavenko, O., Escobar, L. (2005). Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats. Transplantation Proceedings 37 (1) : 470-471. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2004.11.057 | |
dc.identifier.issn | 00411345 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/30514 | |
dc.description.abstract | The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats. © 2005 by Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.transproceed.2004.11.057 | |
dc.source | Scopus | |
dc.type | Conference Paper | |
dc.contributor.department | PATHOLOGY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1016/j.transproceed.2004.11.057 | |
dc.description.sourcetitle | Transplantation Proceedings | |
dc.description.volume | 37 | |
dc.description.issue | 1 | |
dc.description.page | 470-471 | |
dc.description.coden | TRPPA | |
dc.identifier.isiut | 000228091300155 | |
Appears in Collections: | Staff Publications |
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