Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2006.11.047
Title: Vitrification as a prospect for cryopreservation of tissue-engineered constructs
Authors: Kuleshova, L.L. 
Gouk, S.S. 
Hutmacher, D.W. 
Keywords: Cryopreservation
Freezing
Tissue-engineered constructs
Vitrification
Issue Date: 2007
Source: Kuleshova, L.L., Gouk, S.S., Hutmacher, D.W. (2007). Vitrification as a prospect for cryopreservation of tissue-engineered constructs. Biomaterials 28 (9) : 1585-1596. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.11.047
Abstract: Cryopreservation plays a significant function in tissue banking and will presume yet larger value when more and more tissue-engineered products will routinely enter the clinical arena. The most common concept underlying tissue engineering is to combine a scaffold (cellular solids) or matrix (hydrogels) with living cells to form a tissue-engineered construct (TEC) to promote the repair and regeneration of tissues. The scaffold and matrix are expected to support cell colonization, migration, growth and differentiation, and to guide the development of the required tissue. The promises of tissue engineering, however, depend on the ability to physically distribute the products to patients in need. For this reason, the ability to cryogenically preserve not only cells, but also TECs, and one day even whole laboratory-produced organs, may be indispensable. Cryopreservation can be achieved by conventional freezing and vitrification (ice-free cryopreservation). In this publication we try to define the needs versus the desires of vitrifying TECs, with particular emphasis on the cryoprotectant properties, suitable materials and morphology. It is concluded that the formation of ice, through both direct and indirect effects, is probably fundamental to these difficulties, and this is why vitrification seems to be the most promising modality of cryopreservation. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/30196
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2006.11.047
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