Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2006.08.032
Title: RhoA protein expression correlates positively with degree of malignancy in astrocytomas
Authors: Yan, B.
Peh, B.K. 
Salto-Tellez, M. 
Chour, H.H.
Lim, C. 
Keywords: Astrocytomas
Malignancy
Protein expression
RhoA
Issue Date: 2006
Source: Yan, B., Peh, B.K., Salto-Tellez, M., Chour, H.H., Lim, C. (2006). RhoA protein expression correlates positively with degree of malignancy in astrocytomas. Neuroscience Letters 407 (2) : 124-126. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2006.08.032
Abstract: Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion, has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas. © 2006 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/30178
ISSN: 03043940
DOI: 10.1016/j.neulet.2006.08.032
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

22
checked on Nov 29, 2017

Page view(s)

124
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.