Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/29934
Title: Study of the morphological and functional alterations of high endothelial venules in the regional lymph nodes to tongue cancer patients and its clinico-pathological correlations
Authors: LEE SER YEE
Keywords: High endothelial venules, lymph nodes, metastasis, tongue cancer
Issue Date: 1-Dec-2010
Source: LEE SER YEE (2010-12-01). Study of the morphological and functional alterations of high endothelial venules in the regional lymph nodes to tongue cancer patients and its clinico-pathological correlations. ScholarBank@NUS Repository.
Abstract: Squamous cell carcinoma of the tongue is one of the most prevalent tumors of the head and neck region. The extent of lymph node metastasis is a major determinant for the staging, the most reliable adverse factor for prognosis of squamous cell carcinoma of the tongue and it guides therapeutic decisions. The Paget?s ?Seed and Soil? theory for cancer and its metastasis is well known and established. Angiogenesis and lymphangiogenesis are both important processes contributing to tumor progression and metastasis. Cancer research has been driven to understand tumor-induced angiogenesis and lymphangiogenesis. Primary tumors can induce lymph channel and vasculature reorganizations within sentinel lymph nodes before the arrival of cancer cells. The key blood vessels in such lymph nodes that are remodeled are identified as high endothelial venules (HEV). The morphological altera?tion of HEV in the presence of a cancer, coupled with the increased proliferation rate of the endothelial cells, results in a functional shifting of HEV from immune response mediator to blood flow carrier. Previous studies have demonstrated the role of HEV in inflammatory setting. It was demonstrated that a cancer-induced reorganization is quite different from an endotoxin induced inflammatory alteration. Our preliminary studies of HEV and its role in lymph nodes of patients with squamous cell carcinoma of the tongue with clinico-pathological correlations revealed a relationship between HEV, cancer metastasis and clinical outcome. These pathological processes are reviewed and clinical phenomena explained in the aid of developing novel therapeutics and prevention strategies against cancer metastasis in the future.
URI: http://scholarbank.nus.edu.sg/handle/10635/29934
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