Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/29864
Title: In Vitro and In Vivo Evaluation of Transferrin-conjugated Lipid Shell and Polymer Core Nanoparticles for Targeted Delivery of Docetaxel
Authors: PHYO WAI MIN
Keywords: Biodegradable polymers, anticancer drugs, cancer nanotechnology, nanomedicine, chemotherapeutic engineering, drug targeting.
Issue Date: 21-Jan-2011
Source: PHYO WAI MIN (2011-01-21). In Vitro and In Vivo Evaluation of Transferrin-conjugated Lipid Shell and Polymer Core Nanoparticles for Targeted Delivery of Docetaxel. ScholarBank@NUS Repository.
Abstract: Lipid shell and polymer core drug delivery systems are increasing popular due to combinations of merits from liposomes and polymeric nanoparticles. The nanoparticles of PLGA as the core and various lipids as the shell were produced by nanoprecipitation method. Transferrin was used as the targeting ligand. Series of characterization of the nanoparticles were carried out by laser light scattering (LLS) for particle size and size distribution, zeta potential analyzer for surface charge and FESEM for surface morphology. XPS and TEM were used to confirm the presence of lipid. The drug encapsulation efficiency (EE) of docetaxel-loaded nanoparticles was measured by HPLC. The size, surface charge and EE of the nanoparticles were found to be correlated to lipid type and quantity. Moreover, in vivo pharmacokinetics study, complete blood count analysis and toxicity assessment of clearance organs were carried out in order to demonstrate the prospect of the formulation as drug delivery system.
URI: http://scholarbank.nus.edu.sg/handle/10635/29864
Appears in Collections:Master's Theses (Open)

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