Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(99)01258-2
Title: Superoxide anion inhibits drug-induced tumor cell death
Authors: Pervaiz, S. 
Hirpara, J.L. 
Ramalingam, J.K. 
Clement, M.-V. 
Keywords: Apoptosis
Caspase
Chemotherapy
Superoxide anion
Issue Date: 1999
Source: Pervaiz, S.,Hirpara, J.L.,Ramalingam, J.K.,Clement, M.-V. (1999). Superoxide anion inhibits drug-induced tumor cell death. FEBS Letters 459 (3) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01258-2
Abstract: Intracellular superoxide (O2(.-)) was manipulated in M14 melanoma cells by overexpression or repression of Cu/Zn SOD using a tetracycline-inducible expression system. Scavenging intracellular O2(.-) increased tumor cell sensitivity to daunorubicin, etoposide, and pMC540, whereas expression of the antisense SOD mRNA significantly decreased cell sensitivity to drug treatment. Whereas Cu/Zn SOD overexpressing cells exhibited higher activation of the executioner caspase 3 upon drug exposure, caspase 3 activation was significantly lower when Cu/Zn SOD was repressed by antisense expression. These data show that intracellular O2(.-) regulates tumor cell response to drug-induced cell death via a direct or indirect effect on the caspase activation pathway. Copyright (C) 1999 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/29733
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)01258-2
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