Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2004.01.026
Title: Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat
Authors: Khanna, S. 
Chang, L.S.
Jiang, F.
Koh, H.C. 
Keywords: Formalin model
Fos
Hippocampus
Noxious intensity-dependent
Pain modulation: anatomy and physiology
Pyramidal cell layer
Sensory systems
Spinal cord
Issue Date: 2004
Source: Khanna, S.,Chang, L.S.,Jiang, F.,Koh, H.C. (2004). Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat. Brain Research 1004 (1-2) : 167-176. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2004.01.026
Abstract: To test the hypothesis that the hippocampus field CA1 is recruited in nociceptive intensity-dependent fashion in the formalin model of inflammatory pain, we determined the effect of injection of formalin (0.625-2.5%) on the induction of Fos protein along the length of the hippocampus. Compared to injection of saline, injection of formalin (0.625-2.5%) evoked a concentration-dependent increase in nociceptive behavior and a significant linear increase in the number of Fos-positive cells in the spinal cord, especially in the deeper laminae. Injection of saline also increased induction of Fos along the length of hippocampus. On the other hand, injection of formalin decreased the number of Fos-positive cells in whole CA1, CA3 and dentate gyrus, with a greater significant effect in the posterior-ventral regions of the hippocampus. Indeed, a formalin concentration-dependent decrease was observed in the ventral CA1. A systematic pattern of change in Fos induction was not observed in the medial septum region. Of the regions examined, only the formalin-induced changes in Fos cell counts in the posterior and ventral CA1 were tightly correlated with the changes observed in the spinal cord. The foregoing findings suggest that nociceptive information is processed in distributed fashion by the hippocampus, and at least the ventral CA1 is implicated in nociceptive intensity-dependent integrative functions. © 2004 Elsevier B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/29654
ISSN: 00068993
DOI: 10.1016/j.brainres.2004.01.026
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

39
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

37
checked on Nov 4, 2017

Page view(s)

140
checked on Dec 16, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.