Please use this identifier to cite or link to this item:
|Title:||Myoblast transplantation for cardiac repair: A clinical perspective|
|Authors:||Haider, H.K. |
|Citation:||Haider, H.K., Tan, A.C.K., Sim, E.K.W., Aziz, S., Chachques, J.C. (2004). Myoblast transplantation for cardiac repair: A clinical perspective. Molecular Therapy 9 (1) : 14-23. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ymthe.2003.10.009|
|Abstract:||The incidence of heart failure is achieving epidemic proportions. Adult human myocytes cannot regenerate because these cells do not reenter the cell cycle. In patients with heart failure, myoblast transplantation is emerging as a potential therapeutic option to augment the function of remaining myocytes. Both skeletal myoblasts and autologous bone marrow cell transplantation, after intensive preclinical experimental animal studies, have entered phase I safety studies in humans. Most of these clinical trials have involved small groups of patients and cell transplantation was carried out as an adjunct to coronary revascularization. Preliminary results show that the procedure is safe and leads to improved myocardial function. This paper reviews and summarizes the outcome of these phase I trials involving skeletal myoblast transplantation.|
|Source Title:||Molecular Therapy|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 12, 2019
WEB OF SCIENCETM
checked on Jan 2, 2019
checked on Dec 29, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.