Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ymthe.2003.10.009
Title: Myoblast transplantation for cardiac repair: A clinical perspective
Authors: Haider, H.K. 
Tan, A.C.K.
Sim, E.K.W. 
Aziz, S.
Chachques, J.C.
Keywords: Cardiac
Clinical
Heart failure
Human
Myoblast
Transplantation
Issue Date: 2004
Source: Haider, H.K., Tan, A.C.K., Sim, E.K.W., Aziz, S., Chachques, J.C. (2004). Myoblast transplantation for cardiac repair: A clinical perspective. Molecular Therapy 9 (1) : 14-23. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ymthe.2003.10.009
Abstract: The incidence of heart failure is achieving epidemic proportions. Adult human myocytes cannot regenerate because these cells do not reenter the cell cycle. In patients with heart failure, myoblast transplantation is emerging as a potential therapeutic option to augment the function of remaining myocytes. Both skeletal myoblasts and autologous bone marrow cell transplantation, after intensive preclinical experimental animal studies, have entered phase I safety studies in humans. Most of these clinical trials have involved small groups of patients and cell transplantation was carried out as an adjunct to coronary revascularization. Preliminary results show that the procedure is safe and leads to improved myocardial function. This paper reviews and summarizes the outcome of these phase I trials involving skeletal myoblast transplantation.
Source Title: Molecular Therapy
URI: http://scholarbank.nus.edu.sg/handle/10635/29511
ISSN: 15250016
DOI: 10.1016/j.ymthe.2003.10.009
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