Please use this identifier to cite or link to this item:
|Title:||Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates|
|Authors:||Isaac, J.R. |
|Source:||Isaac, J.R., Khoo, A., Calne, R., Wang, D.Z., Lee, K.O., Salto-Tellez, M., Skinner, S., Elliot, R., Garkavenko, O. (2005). Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates. Transplantation Proceedings 37 (1) : 487-488. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2004.11.062|
|Abstract:||A Mexican group reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with sertoli cells (islet/sertoli cells) into an omental site and other locations of seven nondiabetic, nonimmunosuppressed, nonhuman primates. Porcine endogenous retrovirus was not detected in recipient blood 8 weeks after porcine islet grafts, and porcine C-peptide was detected at a very low level in all animals. Histology examination failed to demonstrate obviously recognizable islets, but in the animals transplanted with islet/Sertoli cells at the omentum site, there were some surviving glucagons, pan-cytokeratin, and inhibin stained cells at 8 weeks. © 2005 by Elsevier Inc. All rights reserved.|
|Source Title:||Transplantation Proceedings|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 14, 2017
WEB OF SCIENCETM
checked on Nov 20, 2017
checked on Dec 17, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.