Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2004.06.099
Title: Runx3-/-gastric epithelial cells differentiate into intestinal type cells
Authors: Fukamachi, H.
Ito, K. 
Ito, Y. 
Keywords: Cdx2
Gastric cancer
Intestinal metaplasia
Runx3
Transdifferentiation
Issue Date: 2004
Source: Fukamachi, H., Ito, K., Ito, Y. (2004). Runx3-/-gastric epithelial cells differentiate into intestinal type cells. Biochemical and Biophysical Research Communications 321 (1) : 58-64. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2004.06.099
Abstract: We have previously reported that Runx3, a runt domain transcription factor, is a major growth regulator of gastric epithelial cells, that a lack of RUNX3 function is causally related to the genesis and progression of human gastric cancer, and that expression of RUNX3 is greatly reduced in intestinal metaplasias in human stomachs. Here we examined the differentiation of Runx3-/- mouse gastric epithelial cells and found that some cells differentiated into intestinal type cells, which expressed Cdx2, a transcription factor that has been shown to induce intestinal metaplasia in transgenic mice. Differentiation of intestinal type cells was not found in culture of Runx3 +/+ gastric epithelial cells. These results suggest that gastric epithelial cells can differentiate into intestinal type cells, probably due to expression of Cdx2 in them when the function of Runx3 is impaired. The relationship between loss of function of Runx3, formation of intestinal metaplasia, and gastric cancer was discussed. © 2004 Elsevier Inc.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/29056
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2004.06.099
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