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|Title:||Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus|
|Authors:||Chan, S.H. |
|Citation:||Chan, S.H., Wee, G.B., Thai, A.C., Liu, K.F., Lin, Y.N. (1995). Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus. Human Immunology 44 (3) : 175-180. ScholarBank@NUS Repository.|
|Abstract:||IDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQβ chains and a lower frequency of homozygous Asp57 DQβ chains compared to controls, especially in younger onset patients.|
|Source Title:||Human Immunology|
|Appears in Collections:||Staff Publications|
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