Please use this identifier to cite or link to this item:
|Title:||Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus|
|Authors:||Chan, S.H. |
|Citation:||Chan, S.H., Wee, G.B., Thai, A.C., Liu, K.F., Lin, Y.N. (1995). Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus. Human Immunology 44 (3) : 175-180. ScholarBank@NUS Repository.|
|Abstract:||IDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQβ chains and a lower frequency of homozygous Asp57 DQβ chains compared to controls, especially in younger onset patients.|
|Source Title:||Human Immunology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 13, 2018
WEB OF SCIENCETM
checked on May 8, 2018
checked on May 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.