Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2005.10.059
Title: Cdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology
Authors: Aulia, S. 
Tang, B.L. 
Keywords: Alzheimer's disease
Anaphase-promoting complex/cyclosome
Cdh1
Cell cycle
Cyclin B
Neuron
Issue Date: 2006
Source: Aulia, S., Tang, B.L. (2006). Cdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology. Biochemical and Biophysical Research Communications 339 (1) : 1-6. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2005.10.059
Abstract: The anaphase-promoting complex/cyclosome (APC/C) is a key E3 ubiquitin ligase complex that functions in regulating cell cycle transitions in proliferating cells and has, as revealed recently, novel roles in postmitotic neurons. Regulated by its activator Cdh1 (or Hct1), whose level is high in postmitotic neurons, APC/C seems to have multiple functions at different cellular locations, modulating diverse processes such as synaptic development and axonal growth. These processes do not, however, appear to be directly connected to cell cycle regulation. It is now shown that Cdh1-APC/C activity may also have a basic role in suppressing cyclin B levels, thus preventing terminally differentiated neurons from aberrantly re-entering the cell cycle. The result of an aberrant cyclin B-induced S-phase entry, at least for some of these neurons, would be death via apoptosis. Cdh1 thus play an active role in maintaining the terminally differentiated, non-cycling state of postmitotic neurons-a function that could become impaired in Alzheimer's and other neurodegenerative diseases. © 2005 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/28736
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2005.10.059
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