Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2009.11.016
Title: Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?
Authors: Tang, B.L. 
Chua, C.E.L.
Keywords: AMP-activated kinase (AMPK)
Caloric restriction
Metabolic syndrome
Sirt1
Issue Date: 2010
Source: Tang, B.L., Chua, C.E.L. (2010). Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?. Biochemical and Biophysical Research Communications 391 (1) : 6-10. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2009.11.016
Abstract: Sir2/Sirt1, a mediator of longevity in several animal models, is a member of the sirtuin family of type III histone deacetylases. Its non-histone substrates include a group of regulatory molecules that modulate energy metabolism, such as peroxisome proliferator-activated receptor-γ (PPARγ), and its transcriptional coactivator, PPARγ coactivator-1α (PGC-1α). Sirt1's activity on these substrates may underlie its connection with the metabolic changes brought about by caloric restriction (CR). Recent studies have elucidated new substrates for Sirt1 that are involved in metabolic regulation, and have further delineated Sirt1's functional associations with other metabolic regulators like AMP-activated kinase (AMPK). Perplexingly, manipulations that either increase or decrease Sirt1 activity have both been associated with a beneficial effect in animal models of ageing-associated disorders, such as neurodegenerative diseases. Sirt1's activation patterns and roles in energy metabolism appear to have tissue specific differences. A deeper understanding of the mechanistic underpinnings of Sirt1's metabolic functions is necessary to effectively design Sirt1-based therapeutic interventions for metabolic disorders. © 2009 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/28716
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2009.11.016
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

7
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

7
checked on Dec 11, 2017

Page view(s)

128
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.