Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.molbrainres.2005.05.016
Title: Tissue expression of alternatively spliced GFRα1, NCAM and RET isoforms and the distinct functional consequence of ligand-induced activation of GFRα1 isoforms
Authors: Yoong, L.F. 
Peng, Z.N.
Wan, G.
Too, H.-P. 
Keywords: Alternative spliced isoform
GDNF
GFRa1
NCAM
RET
Issue Date: 2005
Source: Yoong, L.F., Peng, Z.N., Wan, G., Too, H.-P. (2005). Tissue expression of alternatively spliced GFRα1, NCAM and RET isoforms and the distinct functional consequence of ligand-induced activation of GFRα1 isoforms. Molecular Brain Research 139 (1) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molbrainres.2005.05.016
Abstract: Glial-cell-line-derived neurotrophic factor (GDNF) exerts its effect through a multi-component receptor system consisting of GFRα1, RET and NCAM. Two highly homologous alternatively spliced GFRα1 isoforms (GFRα1a and GFRα1b) have previously been identified. In this study, isoform specific real-time PCR assays were used to quantify the expression levels of GFRα1, RET and NCAM isoforms in murine embryonic and adult tissues. The expression levels of GFRα1b were found to be comparable to that of GFRα1a in peripheral tissues. However, GFRα1a was the predominant isoform expressed in the whole brain. The co-expressions of GFRα1 and the co-receptors were developmentally regulated and differentially expressed in some tissues. Microarray analyses of GFRα1 isoforms transfected cells stimulated with NTN showed distinct and non-overlapping gene profiles. These observations are consistent with the emerging view that the combinatorial interactions of the spliced isoforms of GFRα, RET and NCAM may contribute to the pleiotropic biological responses. © 2005 Elsevier B.V. All rights reserved.
Source Title: Molecular Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/28677
ISSN: 0169328X
DOI: 10.1016/j.molbrainres.2005.05.016
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

13
checked on Dec 13, 2017

Page view(s)

115
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.