Please use this identifier to cite or link to this item:
|Title:||Nonvesicular sterol transport: two protein families and a sterol sensor?|
|Source:||Yang, H. (2006). Nonvesicular sterol transport: two protein families and a sterol sensor?. Trends in Cell Biology 16 (9) : 427-432. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2006.07.002|
|Abstract:||Sterols, essential components of eukaryotic membranes, are actively transported between cellular membranes. Although it is known that both vesicular and non-vesicular means are used to move sterols, the molecules and molecular mechanisms involved have yet to be identified. Recent studies point to a key role for oxysterol binding protein (OSBP) and its related proteins (ORPs) in nonvesicular sterol transport. Here, evidence that OSBP and ORPs are bona fide sterol carriers is discussed. In addition, I hypothesize that ATPases associated with various cellular activities regulate the recycling of soluble lipid carriers and that the Niemann Pick C1 protein facilitates the delivery of sterols from endosomal membranes to ORPs and/or the ensuing membrane dissociation of ORPs. © 2006 Elsevier Ltd. All rights reserved.|
|Source Title:||Trends in Cell Biology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 13, 2017
WEB OF SCIENCETM
checked on Nov 4, 2017
checked on Dec 9, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.