Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tcb.2006.07.002
Title: Nonvesicular sterol transport: two protein families and a sterol sensor?
Authors: Yang, H. 
Issue Date: 2006
Source: Yang, H. (2006). Nonvesicular sterol transport: two protein families and a sterol sensor?. Trends in Cell Biology 16 (9) : 427-432. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2006.07.002
Abstract: Sterols, essential components of eukaryotic membranes, are actively transported between cellular membranes. Although it is known that both vesicular and non-vesicular means are used to move sterols, the molecules and molecular mechanisms involved have yet to be identified. Recent studies point to a key role for oxysterol binding protein (OSBP) and its related proteins (ORPs) in nonvesicular sterol transport. Here, evidence that OSBP and ORPs are bona fide sterol carriers is discussed. In addition, I hypothesize that ATPases associated with various cellular activities regulate the recycling of soluble lipid carriers and that the Niemann Pick C1 protein facilitates the delivery of sterols from endosomal membranes to ORPs and/or the ensuing membrane dissociation of ORPs. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Trends in Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/28626
ISSN: 09628924
DOI: 10.1016/j.tcb.2006.07.002
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