Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cub.2009.10.074
Title: Mitochondrial Cardiolipin Involved in Outer-Membrane Protein Biogenesis: Implications for Barth Syndrome
Authors: Gebert, N.
Kutik, S.
Becker, T.
Stroud, D.A.
Meisinger, C.
Wiedemann, N.
Pfanner, N.
Joshi, A.S.
Kulkarni, G.
Greenberg, M.L.
McKenzie, M.
Mooga, V.P.
Ryan, M.T.
Guan, X.L. 
Wenk, M.R. 
Rehling, P.
Keywords: CELLBIO
Issue Date: 2009
Source: Gebert, N., Kutik, S., Becker, T., Stroud, D.A., Meisinger, C., Wiedemann, N., Pfanner, N., Joshi, A.S., Kulkarni, G., Greenberg, M.L., McKenzie, M., Mooga, V.P., Ryan, M.T., Guan, X.L., Wenk, M.R., Rehling, P. (2009). Mitochondrial Cardiolipin Involved in Outer-Membrane Protein Biogenesis: Implications for Barth Syndrome. Current Biology 19 (24) : 2133-2139. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cub.2009.10.074
Abstract: The biogenesis of mitochondria requires the import of a large number of proteins from the cytosol [1, 2]. Although numerous studies have defined the proteinaceous machineries that mediate mitochondrial protein sorting, little is known about the role of lipids in mitochondrial protein import. Cardiolipin, the signature phospholipid of the mitochondrial inner membrane [3-5], affects the stability of many inner-membrane protein complexes [6-12]. Perturbation of cardiolipin metabolism leads to the X-linked cardioskeletal myopathy Barth syndrome [13-18]. We report that cardiolipin affects the preprotein translocases of the mitochondrial outer membrane. Cardiolipin mutants genetically interact with mutants of outer-membrane translocases. Mitochondria from cardiolipin yeast mutants, as well as Barth syndrome patients, are impaired in the biogenesis of outer-membrane proteins. Our findings reveal a new role for cardiolipin in protein sorting at the mitochondrial outer membrane and bear implications for the pathogenesis of Barth syndrome. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Current Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/28614
ISSN: 09609822
DOI: 10.1016/j.cub.2009.10.074
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

121
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

115
checked on Nov 18, 2017

Page view(s)

156
checked on Dec 17, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.