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Title: Polymeric Nanofiber Conduits for Peripheral Nerve Regeneration
Keywords: nerve, regeneration, fibers, electrospinning, biomaterials, axons
Issue Date: 28-May-2009
Citation: KOH HUI SHAN (2009-05-28). Polymeric Nanofiber Conduits for Peripheral Nerve Regeneration. ScholarBank@NUS Repository.
Abstract: Synthetic polymer nanofiber conduit was fabricated to act as a guiding construct for peripheral nerve gap repair. The conduit consisted of two layers of nanofiber membranes - inner layer of aligned nanofibers to guide axon outgrowth; outer layer of randomly arranged nanofibers to provide mechanical integrity. Furthermore, intra-luminal guidance channels made from strands of aligned nanofibers were fabricated to closely imitate the intact nerve architecture of the basal laminae and bands of BC<ngner that allow the Schwann cells and axons to orientate along the axis of the aligned nanofibers. Extracellular matrix proteins and neurotrophins were coupled onto the nanofibers to improve the functional performance of the designed nerve construct. Finally, the biomimetic nanofibrous conduit containing guidance channels was shown to support nerve regeneration across 10mm rat sciatic nerve interstump gap effectively with improved functional recovery in peripheral nerve injury repair.
Appears in Collections:Ph.D Theses (Open)

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