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Title: Role of Abberant Proteolysis in the Pathogenesis of APL
Keywords: Unfolded Protein Response, Autophagy, ER stress, Acute Promyelocytic Leukemia, Apoptosis, N-CoR
Issue Date: 26-May-2009
Citation: NG PING PING ANGELA (2009-05-26). Role of Abberant Proteolysis in the Pathogenesis of APL. ScholarBank@NUS Repository.
Abstract: Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). Although accumulation of misfolded proteins is known to trigger UPR-induced cytotoxic cell death in several neurodegenerative disorders, APL cells are notably resistant to UPR-induced apoptosis. This project was initiated with the goals to investigate how N-CoR misfolding supports the survival and growth of APL cells, and to screen potential therapeutic agents that could induce growth arrest through targeting the misfolded N-CoR-induced survival pathways in APL.
Appears in Collections:Ph.D Theses (Open)

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