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https://scholarbank.nus.edu.sg/handle/10635/28308
DC Field | Value | |
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dc.title | Cytomegalovirus infections in Solid Organ transplant recipients | |
dc.contributor.author | YEO CHAO CHUANG, ADRIAN | |
dc.date.accessioned | 2011-11-08T18:03:54Z | |
dc.date.available | 2011-11-08T18:03:54Z | |
dc.date.issued | 2007-12-27 | |
dc.identifier.citation | YEO CHAO CHUANG, ADRIAN (2007-12-27). Cytomegalovirus infections in Solid Organ transplant recipients. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/28308 | |
dc.description.abstract | Published data on the impact of cytomegalovirus (CMV) infection and disease in Singapore is limited. Laboratory investigations of CMV ganciclovir resistance revealed its presence in 25% of renal and 40% of liver transplant recipients. We improved on genotypic screening methods by developing several rapid PCR-based assays for detection of specific mutations in CMV which could be utilized directly on clinical samples. The association between CMV infection and disease on long-term outcome after kidney transplantation is still unsettled. Logistic regression analyses of clinical data from our prospective study of 119 consecutive renal transplant subjects showed a significant correlation between allograft dysfunction at one year post-transplant and presence of CMV DNAemia at five months post-transplant (P< 0.01; OR 2.864, 95% CI 1.046-7.839). We also observed that presence of IgG specific anti-endothelial cell antibody (AECA) activity was significantly associated with CMV DNAemia (P < 0.01). | |
dc.language.iso | en | |
dc.subject | cytomegalovirus, solid organ transplant recipients, resistance | |
dc.type | Thesis | |
dc.contributor.department | PAEDIATRICS | |
dc.contributor.supervisor | YAP HUI KIM | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Yeo Chao Chuang Adrian PHD Paediatrics CMV infections in solid organ transplant recipients 2006.pdf | 1.14 MB | Adobe PDF | OPEN | None | View/Download |
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