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Title: Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore
Keywords: Pharmacokinetics; Pharmacogenetics; Mycophenolic acid; Asian; Renal transplant
Issue Date: 21-May-2008
Citation: YAU WAI PING (2008-05-21). Pharmacokinetics and pharmacogenetics of mycophenolic acid in Asian renal transplant patients in Singapore. ScholarBank@NUS Repository.
Abstract: The first part of this thesis evaluated the acute and steady-state pharmacokinetics (PK) of the immunosuppressant, mycophenolic acid (MPA), and its glucuronide metabolite (MPAG) in Asian renal transplant recipients (RTxR) in Singapore. Reversed-phase liquid chromatographic assays were developed for the quantification of total and free MPA and MPAG in human plasma and urine, which were applied to the clinical PK studies. The MPA oral clearance showed tendency to be lower in Asians than the Western population and a wide inter-subject variability in the PK parameters of MPA and MPAG in the Asian RTxR was also observed. The second part of this thesis thus investigated genetic variations in uridine diphosphate glucuronosyltransferases, the metabolic enzymes of MPA, as potential contributing factors underlying these PK observations. The pharmacogenetics findings, together with PK results and non-genetic patient factors, may potentially aid in the individualization of mycophenolate therapy to enhance efficacy and safety in Asian RTxR.
Appears in Collections:Ph.D Theses (Open)

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