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Title: A proteomic approach for the identification of HCC serum biomarkers
Authors: LOW JIAYI
Keywords: tumour-associated autoantigens; proteomics; HCC; biomarker
Issue Date: 12-Jun-2008
Citation: LOW JIAYI (2008-06-12). A proteomic approach for the identification of HCC serum biomarkers. ScholarBank@NUS Repository.
Abstract: Hepatocellular carcinoma (HCC), generally known as primary liver cancer, is a common malignancy with a high mortality rate. The mortality rate can be significantly lowered if diagnosis is made early. Since cirrhosis precedes 80% of HCC cases, the detection of cirrhosis can facilitate early HCC detection. Early biomarkers of cirrhosis and HCC are therefore urgently needed. In this work, we aim to identify cirrhosis- and HCC-associated autoantibodies that enable the early detection of HCC. These autoantibodies are elicited during early carcinogenesis, and are possibly the earliest cancer biomarkers that can be detected in sera. In this study, tumour proteins were separated by 2-DE before being transferred onto PVDF membranes and probed with patient or control sera. The immunoreactive profiles were compared and twelve cirrhosis- and HCC-associated antigenic spots were detected and identified by tandem mass spectrometry. Six of these autoantigens can potentially form a biomarker panel for the detection of cirrhosis and HCC. In conclusion, this study identified a distinct repertoire of cirrhosis- and HCC-associated autoantibodies that can potentially enable early HCC diagnosis.
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