Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28267
Title: Roles of BNIP-H in cell dynamics control
Authors: CHEW LI LI
Keywords: BNIP-H Kinesin KHC Caytaxin Glutaminase KGA
Issue Date: 2-May-2008
Source: CHEW LI LI (2008-05-02). Roles of BNIP-H in cell dynamics control. ScholarBank@NUS Repository.
Abstract: BNIP-H, also known as caytaxin, is a BCH domain containing neuronal protein implicated in disease model such as cayman ataxia and dystonia in human, mice and rats. Although the phenotypic expression of BNIP-H mutations had been well characterized, the precise mechanism through which BNIP-H function remains elusive. To establish its role in neuronal differentiation, BNIP-H was ectopically expressed in PC12 and cells transfected with BNIP-H was found to possess longer neurite processes when stimulated with non-saturating concentration of NGF. Further studies showed this enhanced neurite outgrowth to be dependent on kinesin dependent BNIP-H transport to the tips of neurites and its interaction with KGA. Parallel study of PC12 transfected with BNIP-H showed enhanced glutamate release to extracellular media. These results suggested that BNIP-H could regulate glutamate biogenesis and probably exocytosis for proper neuronal growth and a loss-of-function mutation in BNIP-H expression could deregulate glutamate homeostasis leading to ataxia and dystonia.
URI: http://scholarbank.nus.edu.sg/handle/10635/28267
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Introduction.pdf7.89 MBAdobe PDF

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MATERIALS AND METHODS.pdf172.26 kBAdobe PDF

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RESULTS - 1.pdf4.36 MBAdobe PDF

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Discussion Conclusion N future work.pdf465.44 kBAdobe PDF

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REFERENCES.pdf115.89 kBAdobe PDF

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