Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28203
Title: Development and applications of novel solvent-minimized techniques in the determination of chemical warfare agents and their degradation products
Authors: LEE HOI SIM, NANCY
Keywords: hollow fiber, liquid-phase microextraction, chemical warfare agents, degradation products, gas chromatography-mass spectrometry, silylation
Issue Date: 4-Jun-2009
Source: LEE HOI SIM, NANCY (2009-06-04). Development and applications of novel solvent-minimized techniques in the determination of chemical warfare agents and their degradation products. ScholarBank@NUS Repository.
Abstract: Two approaches towards the development of solvent-minimised microextraction techniques are presented in this report. The first approach involved an attempt to develop solid-phase microextraction (SPME) fibres based on molecularly imprinted polymers (MIP) synthesised via the sol-gel route for the extraction of degradation products of chemical warfare agents. Sol-gel MIPs were first evaluated as sorbent packings in solid-phase extraction (SPE) cartridges. A series of MIPs together with a corresponding non-imprinted polymer were evaluated for their binding properties towards their respective target analytes in aqueous matrices. In addition, a novel SPME coating was investigated and its performance was compared against that of commercially-available SPME coatings.In the second approach, hollow fibre-protected liquid-phase microextraction (HF-LPME) was utilised for the determination of various chemical warfare agents and their degradation products. The applicability of the technique for a 20th Official Organisation for the Prohibition of Chemical Weapons Proficiency Test sample was demonstrated.
URI: http://scholarbank.nus.edu.sg/handle/10635/28203
Appears in Collections:Ph.D Theses (Open)

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