Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28181
Title: Evaluation of two novel bioreactor systems for tissue engineering applications
Authors: HARMEET SINGH
Keywords: Tissue Engineering, Bioreactors, Computational Fluid Dynamics
Issue Date: 4-Jun-2008
Source: HARMEET SINGH (2008-06-04). Evaluation of two novel bioreactor systems for tissue engineering applications. ScholarBank@NUS Repository.
Abstract: The first part of this thesis studies the impact of fluid flow in scaffolds within two newly designed bioreactors, by means of Computational Fluid Dynamics simulations. The second part of the thesis investigates for cell proliferation numbers. The first system, a rotating-vessel bioreactor, is capable of rotating in a spinning and tumbling manner simultaneously, based on the hypothesis that this would enhance nutritional and waste transport, to and from cells seeded within scaffolds. Cell numbers were compared as the vessel was rotated uni-axially about each axis, and bi-axially. Results showed that bi-axial rotation results in statistically and significantly higher cell numbers. The second system is a conical, non-perfusion system that was designed as part of an in-house collaboration. This economical design was developed for functionality and ease of operation. Results confirmed the functionality of the vessel, as cell growth was reported under specific flow conditions.
URI: http://scholarbank.nus.edu.sg/handle/10635/28181
Appears in Collections:Ph.D Theses (Open)

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B Preface.pdf127.6 kBAdobe PDF

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1 Intro.pdf27.07 kBAdobe PDF

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2 Lit Review.pdf560.42 kBAdobe PDF

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3 Research Outline.pdf68.16 kBAdobe PDF

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4 Matls and Methods.pdf293.85 kBAdobe PDF

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5 Part I Design.pdf207.69 kBAdobe PDF

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5 Part II CFD.pdf11.19 MBAdobe PDF

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5 Part III Experiments.pdf4.36 MBAdobe PDF

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5 Part IV Summary.pdf23.51 kBAdobe PDF

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6 Part I Design.pdf221.65 kBAdobe PDF

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6 Part II CFD.pdf3.79 MBAdobe PDF

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6 Part III Experiments.pdf184.19 kBAdobe PDF

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6 Part IV Summary.pdf13.41 kBAdobe PDF

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7 Conclusions.pdf27.61 kBAdobe PDF

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8 References.pdf84.68 kBAdobe PDF

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