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Title: Investigation into the roles of Ataxia Telangiectasia mutated gene product, in multiple BRCA backgrounds
Keywords: ATM, BAC recombineering, RNA interference, Irradiation, Etoposide, Chk2
Issue Date: 16-May-2008
Citation: HIONG KUM CHEW (2008-05-16). Investigation into the roles of Ataxia Telangiectasia mutated gene product, in multiple BRCA backgrounds. ScholarBank@NUS Repository.
Abstract: ATM is a serine-threonine kinase that is activated in response to DNA double strand breaks and is an important sensor for proper repair. Recent investigations reveal that Ataxia-telangiectasia (AT) mutation carriers have an increased risk of developing breast cancer, especially in younger women. To understand further the interplay between ATM and breast cancer susceptibility genes, we initiated studies to investigate the contribution of simultaneous loss of ATM and BRCA function in multiple cell culture based models. We utilized various approaches to investigate the role of ATM in multiple BRCA backgrounds including RNA interference, clonogenic survival and Bacterial Artificial Chromosome engineering to study downstream signaling efficiency, sensitivity to therapy, cell cycling and transformability. Our data suggests that ATM may regulate other signaling pathways via its ability to interact with BRCA1 and/or BRCA2 and that loss of multiple functions could drive cellular transformation and influence responses to therapy.
Appears in Collections:Master's Theses (Open)

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