Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28162
Title: Synthesis of cyclic dipurinic acids as potential inhibitors targeting diguanylate cyclases
Authors: CHING SHI MIN
Keywords: diguanylate cyclase diguanylic acid
Issue Date: 28-May-2009
Citation: CHING SHI MIN (2009-05-28). Synthesis of cyclic dipurinic acids as potential inhibitors targeting diguanylate cyclases. ScholarBank@NUS Repository.
Abstract: Five analogues with the c-di-GMP backbone structure but with varied bases, including c-di-GMP itself were synthesized with reasonable yield of 10-15% after 8 steps. They were designed as antimicrobial agents to inhibit biofilm formation, which is responsible for diseases such as chronic cystic fibrosis and nosocomial bacteremia. These compounds were subsequently tested for biological activities on Slr 1143, diguanylate cyclase of Synechocystis sp., that was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently, purified by affinity chromatography.
URI: http://scholarbank.nus.edu.sg/handle/10635/28162
Appears in Collections:Master's Theses (Open)

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