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https://scholarbank.nus.edu.sg/handle/10635/28159
DC Field | Value | |
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dc.title | Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells | |
dc.contributor.author | TAN HEE MENG ANDY | |
dc.date.accessioned | 2011-11-08T18:01:00Z | |
dc.date.available | 2011-11-08T18:01:00Z | |
dc.date.issued | 2008-03-19 | |
dc.identifier.citation | TAN HEE MENG ANDY (2008-03-19). Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/28159 | |
dc.description.abstract | The inducible costimulator (ICOS) is a member of the CD28 family of costimulatory molecules and plays a central role in T-cell-mediated immunity. In this study, we investigated the molecular regulation of ICOS expression during early activation of CD4+ T cells by T cell receptor and CD28 co-engagement as well as during the differentiation of these cells into Th1 and Th2 lineages. In recently activated T cells, our data suggests that the Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 signaling axes cooperate to transactivate icos transcription by acting on two different sites of its promoter. In T cells undergoing differentiation, we found that T-bet in Th1 or GATA-3 in Th2 cells could enhance, and NFATc2 could further synergize with either of them to increase, icos transcription via the icos promoter or a 3o "UTR element respectively. Finally, we also found that ICOS is controlled at a post-transcriptional level by the RING-type E3 ubiquitin ligase, roquin. | |
dc.language.iso | en | |
dc.subject | inducible costimulator, T cell, T-bet, GATA-3, NFATc2, Th differentiation | |
dc.type | Thesis | |
dc.contributor.department | NUS GRAD SCH FOR INTEGRATIVE SCI & ENGG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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PhD Thesis_Andy Tan_rev270208.pdf | 1.72 MB | Adobe PDF | OPEN | None | View/Download |
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