Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28156
Title: Amino acid substitutions in the epstein-barr virus associated oncogene latent membrane protein 1 impact upon the immunogenicity of Nasopharyngeal carcinoma cells
Authors: SONG ZHENYING
Keywords: Epstein-Barr Virus, latent membrane protein 1, nasopharyngeal carcinoma, antigen presentation
Issue Date: 13-Apr-2009
Source: SONG ZHENYING (2009-04-13). Amino acid substitutions in the epstein-barr virus associated oncogene latent membrane protein 1 impact upon the immunogenicity of Nasopharyngeal carcinoma cells. ScholarBank@NUS Repository.
Abstract: Epstein Barr virus (EBV) is a gamma herpesvirus that is implicated in the development of nasopharyngeal carcinoma (NPC). The control of natural EBV infection is mediated by the CD8+ T-lymphocyte response targeting viral peptides presented on the surface of infected cells in association with MHC class I. In NPC cells, a principle EBV gene product with oncogenic activity is latent membrane protein (LMP1). Whilst an LMP1-specific CD8+ T cell response is detectable in healthy individuals, it is often undetectable in NPC patients. In this study, we provide a mechanistic insight into why the LMP1 associated with NPC cells but not B-lymphocytes is poorly recognised by the human immune system. We show that LMP1 derived from NPC cells contains a number of point mutations and demonstrate that these mutations in LMP1 result in severe impairment in antigen presentation. This has important implications for the treatment of EBV-associated malignancies like NPC.
URI: http://scholarbank.nus.edu.sg/handle/10635/28156
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