Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/28124
Title: Functional and structural genomics study of Singapore grouper iridovirus
Authors: CHEN LIMING
Keywords: SGIV, DNA microarray, iTRAQ, X-ray, SPR
Issue Date: 14-Aug-2008
Source: CHEN LIMING (2008-08-14). Functional and structural genomics study of Singapore grouper iridovirus. ScholarBank@NUS Repository.
Abstract: Singapore grouper iridovirus (SGIV), an iridovirus in the genus Ranavirus, is a major pathogen that results in significant economic losses in grouper aquaculture. In this thesis, first, we report the temporal and differential gene expression of SGIV using SGIV viral DNA microarray; Second, we report the first proteomics study of grouper embryonic cells (GEC) infected by Singapore grouper iridovirus (SGIV) to take an insight into the interaction of SGIV and its host cell at proteome scale by iTRAQ; third, we report that a novel viral coding protein ORF158L is involved in the regulation of host histone H3 K79 methylation; finally, we report the structural study of ORF158L. Our work provides important insights into the pathogenesis of iridoviruses.
URI: http://scholarbank.nus.edu.sg/handle/10635/28124
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
CHEN LIMING_PhD_Thesis_Final Submission.pdf4.21 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

175
checked on Dec 1, 2017

Download(s)

255
checked on Dec 1, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.