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Title: Functional and structural genomics study of Singapore grouper iridovirus
Keywords: SGIV, DNA microarray, iTRAQ, X-ray, SPR
Issue Date: 14-Aug-2008
Citation: CHEN LIMING (2008-08-14). Functional and structural genomics study of Singapore grouper iridovirus. ScholarBank@NUS Repository.
Abstract: Singapore grouper iridovirus (SGIV), an iridovirus in the genus Ranavirus, is a major pathogen that results in significant economic losses in grouper aquaculture. In this thesis, first, we report the temporal and differential gene expression of SGIV using SGIV viral DNA microarray; Second, we report the first proteomics study of grouper embryonic cells (GEC) infected by Singapore grouper iridovirus (SGIV) to take an insight into the interaction of SGIV and its host cell at proteome scale by iTRAQ; third, we report that a novel viral coding protein ORF158L is involved in the regulation of host histone H3 K79 methylation; finally, we report the structural study of ORF158L. Our work provides important insights into the pathogenesis of iridoviruses.
Appears in Collections:Ph.D Theses (Open)

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