Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27949
Title: ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION
Authors: TOH PANG KIAT BENJAMIN
Keywords: cancer, MDSC, EMT, melanoma, RET, immune system
Issue Date: 29-Jun-2011
Source: TOH PANG KIAT BENJAMIN (2011-06-29). ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION. ScholarBank@NUS Repository.
Abstract: In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of selected, random mutations and thus occur late in cancer progression. However, recent studies show that cancer cells disseminate early, implying the existence of a different, faster route to the metastatic motile phenotype. Using a spontaneous murine model of melanoma, I show that a subset of bone marrow-derived immune cells (myeloid-derived suppressor cells or MDSCs) preferentially infiltrates the primary tumor and actively promotes cancer cell dissemination by inducing mesenchymal transition (MT). In vitro and in vivo assays using purified MDSCs showed attraction of MDSCs to the primary tumor is CXCR2-dependent and that TGF-beta, EGF and HGF signaling pathways are all used by MDSCs to induce MT in cancer cells. These findings explain how cancer cells acquire a motile phenotype early and provide a mechanistic explanation for the long recognized link between inflammation and cancer progression.
URI: http://scholarbank.nus.edu.sg/handle/10635/27949
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