Please use this identifier to cite or link to this item:
Title: The roles of Hedgehog signalling in Drosophila postembryonic brain development
Keywords: Drosophila, neural stem cell, Hedgehog, temporal series, asymmetric cell division, cell cycle exit
Issue Date: 13-Apr-2011
Source: CHAI PHING CHIAN (2011-04-13). The roles of Hedgehog signalling in Drosophila postembryonic brain development. ScholarBank@NUS Repository.
Abstract: In Drosophila, neural stem cells called neuroblasts divide asymmetrically to self-renew and to generate differentiated neurons and glial cells. In this thesis, two different aspects of neuroblast division were presented: (i) the involvement of Hedgehog (Hh) signaling in the temporal series; and (ii) the link between temporal series and components of asymmetric cell division. In part (i), I found that Hh signaling was required for the termination of neuroblast cell cycle at pupal stage via down-regulation of Grainyhead expression. Moreover, Hh was primed for expression by the temporal transcription factor, Castor. In part (ii), I showed that Protein Phosphatase 4 interacted genetically with Castor, and it was likely to act through Hh pathway via its role as a Smoothened phosphatase.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChaiPC.pdf7.04 MBAdobe PDF



Page view(s)

checked on Dec 11, 2017


checked on Dec 11, 2017

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.