Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27946
Title: The roles of Hedgehog signalling in Drosophila postembryonic brain development
Authors: CHAI PHING CHIAN
Keywords: Drosophila, neural stem cell, Hedgehog, temporal series, asymmetric cell division, cell cycle exit
Issue Date: 13-Apr-2011
Source: CHAI PHING CHIAN (2011-04-13). The roles of Hedgehog signalling in Drosophila postembryonic brain development. ScholarBank@NUS Repository.
Abstract: In Drosophila, neural stem cells called neuroblasts divide asymmetrically to self-renew and to generate differentiated neurons and glial cells. In this thesis, two different aspects of neuroblast division were presented: (i) the involvement of Hedgehog (Hh) signaling in the temporal series; and (ii) the link between temporal series and components of asymmetric cell division. In part (i), I found that Hh signaling was required for the termination of neuroblast cell cycle at pupal stage via down-regulation of Grainyhead expression. Moreover, Hh was primed for expression by the temporal transcription factor, Castor. In part (ii), I showed that Protein Phosphatase 4 interacted genetically with Castor, and it was likely to act through Hh pathway via its role as a Smoothened phosphatase.
URI: http://scholarbank.nus.edu.sg/handle/10635/27946
Appears in Collections:Ph.D Theses (Open)

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