Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27917
Title: H-RAS 12V INDUCES EXPRESSION OF RAET1 FAMILY NK RECEPTOR LIGANDS
Authors: LIU XI
Keywords: natural killer cells, innate immunity, cancer, NKG2D ligands, H-Ras 12V.
Issue Date: 17-Jun-2011
Source: LIU XI (2011-06-17). H-RAS 12V INDUCES EXPRESSION OF RAET1 FAMILY NK RECEPTOR LIGANDS. ScholarBank@NUS Repository.
Abstract: Natural killer (NK) cells play a crucial role in innate immunity against tumors and infections. Infected cells and tumor cells frequently upregulate ligands for the activating NK cell receptor NKG2D. Here we show that deregulated H-Ras activation induces the expression of Raet1 Family NK Receptor Ligands. H-Ras 12V-induced NKG2D ligand upregulation depended on Raf, MEK and PI3K, but not the DNA damage response-initiating kinases ATM/ATR. Upregulation of NKG2D ligands by H-Ras 12V increased sensitivity of cells to NK cell-mediated cytotoxicity. In summary, our data suggest that hyperactive Ras activity is linked to innate immune responses, which can contribute to immune surveillance of cancer.
URI: http://scholarbank.nus.edu.sg/handle/10635/27917
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