Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27864
Title: Molecular cloning and characterization of novel genes HEPN1, hepaCAM and HEPT3 that are altered in human hepatocellular carcinoma
Authors: MOH MEI CHUNG
Keywords: HEPN1, hepaCAM, HEPT3, Immunoglobulin-like cell adhesion molecule, cell-matrix interaction, cell migration
Issue Date: 10-Aug-2006
Source: MOH MEI CHUNG (2006-08-10). Molecular cloning and characterization of novel genes HEPN1, hepaCAM and HEPT3 that are altered in human hepatocellular carcinoma. ScholarBank@NUS Repository.
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and it presents an extremely poor prognosis. Therefore, delineation of the yet unclear genetic pathways involved in the pathogenesis of HCC may shed light on the development of effective interventions for diagnosis and therapy. Examining genes differentially expressed in HCC using the technique of suppression subtractive hybridization, we identified 272 transcripts that were altered in HCC, among which two novel genes, HEPN1 that was frequently down-regulated in HCC, and HEPT3 that was frequently up-regulated in HCC were selected for our work. Intriguingly, the identification of HEPN1 led us to isolate an uncharacterized gene, hepaCAM, containing the full-length cDNA of HEPN1 on its antisense strand in the 3a??-noncoding region. In this study, we aimed to clone the full-length cDNAs of these three novel genes and to characterize them by investigating their expressions and functions in HCC and in other malignancies.
URI: http://scholarbank.nus.edu.sg/handle/10635/27864
Appears in Collections:Ph.D Theses (Open)

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