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Title: Study of environmentally sensitive polymeric carriers for controlled drug delivery
Keywords: Environmentally sensitive; PNIPAAm; PLGA; Microspheres; Micelles; Drug release.
Issue Date: 23-Jun-2006
Source: LIU SHAOQIONG (2006-06-23). Study of environmentally sensitive polymeric carriers for controlled drug delivery. ScholarBank@NUS Repository.
Abstract: The aim of this study was to design environmentally sensitive microspheres and micelles for controlled delivery of proteins and anticancer drugs. The temperature sensitive block copolymers PNIPAAm-b-PLA and P(NIPAAm-co-DMAAm)-b-PLGA were synthesized, and employed to make microspheres and micelles respectively. In addition, pH-triggered temperature sensitive block copolymer folate-conjugated poly(NIPAAm-co-DMAAm-co-MAm)-b-PUA was synthesized, and utilized to fabricate micelles. These carriers were characterized by drug loading and in vitro drug release. Firstly, BSA was well entrapped within the microspheres. Secondly, anticancer drugs, DOX and paclitaxel, were encapsulated into the micelles made from P(NIPAAm-co-DMAAm)-b-PLGA. Drug release was faster at a temperature above the LCST. Thirdly, the LCST of the micelles made from folate-conjugated poly(NIPAAm-co-DMAAm-co-MAm)-b-PUA and in vitro drug release were pH-dependent. The DOX-loaded micelles with pH-sensitivity had greater cytotoxicity against 4T1 cells and demonstrated a longer circulation time in the blood and higher concentration in tumors as compared to free DOX.
Appears in Collections:Ph.D Theses (Open)

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