Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27852
Title: Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants' sugar metalbolic pathway
Authors: CHUA TECK KHIANG
Keywords: SPS Sucrose-Phospate Synthase FRK Fructokinase Structure Plant
Issue Date: 12-Feb-2009
Source: CHUA TECK KHIANG (2009-02-12). Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants' sugar metalbolic pathway. ScholarBank@NUS Repository.
Abstract: My Ph.D. thesis comprises the elucidation of crystal structure and function of two key enzymes, namely Sucrose phosphate synthase (SPS) and Fructokinase (FRK). We take the Halothermothrix orenii as a model system for the plant enzymes to characterize the structure and function. The structural studies of both enzymes indicate that the H. orenii represent valid models of both plant SPSs and FRKs and thus provide useful insight into the reaction mechanism of the plant enzymes. SPS has been implicated in stress response and food productivity, structure-based mutagenesis of SPS in plants may result in high yielding crops with greater resistance to osmotic fluctuations in the face of climate changes today. Structure based mutagenesis of FRK in plants may have an impact on starch production and also elevating the levels of fructose in developing and ripening fruit for increased sweetness.
URI: http://scholarbank.nus.edu.sg/handle/10635/27852
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