Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27836
Title: The role of Cyr61 and LASP1 in growth and metastasis of human hepatocellular carcinoma
Authors: WANG BEI
Keywords: Cyr61, Lasp1, hepatocellular carcinoma, metastasis, p53, extracellular matrix (ECM)
Issue Date: 21-Mar-2008
Source: WANG BEI (2008-03-21). The role of Cyr61 and LASP1 in growth and metastasis of human hepatocellular carcinoma. ScholarBank@NUS Repository.
Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world with poor prognosis associated with tumor invasion and metastasis. Here we report that two genes - Cyr61 and Lasp1 may play important roles in growth and metastasis of HCC. As a secreted extracellular matrix (ECM)-associated protein, Cyr61 was down-regulated in both HCC tumor tissue and cell lines. Over-expression of Cyr61 suppressed cell proliferation through p53 dependent as well as alternative pathways. Moreover, Cyr61 inhibited cell migration and invasion by interfering with ECM-integrin signaling pathways. In contrast, the focal adhesion scaffolding protein Lasp1 was found to be up-regulated in HCC. Knockdown of Lasp1 by siRNA significantly inhibited cell growth. Alterations in Lasp1 expression inhibited cell migration and invasion, possibly through influencing F-actin dynamics. More interestingly, Lasp1 is transcriptionally regulated and suppressed by p53 binding to its promoter. This work provides new insights into the role of p53 in tumor metastasis.
URI: http://scholarbank.nus.edu.sg/handle/10635/27836
Appears in Collections:Ph.D Theses (Open)

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