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Title: The roles of Lactic acid bacteria in host inflammatory responses
Keywords: Lactic acid bacteria, inflammation, E.faecalis, IL-8, carbohydrates
Issue Date: 7-Mar-2008
Citation: WANG SHUGUI (2008-03-07). The roles of Lactic acid bacteria in host inflammatory responses. ScholarBank@NUS Repository.
Abstract: Intestinal epithelial cells (IECs) regulate the mucosal immune responses upon a variety of stimuli, including lactic acid bacteria (LAB). However, the influence of LAB on the development and regulation of intestinal immunity is unclear. In our study, 56 LAB were tested for their ability to modulate inflammatory responses in human IECs. It was demonstrated that Enterococcus faecalis is the main immune modulator among the LAB by downregulation of IL-8 secretion. Strikingly, the effect was only observed in four strains of E. faecalis out of the 27 strains isolated and tested. In addition, carbohydrates on bacterial cell surface are involved in both its adhesion to intestinal cells and regulation of inflammatory responses in the host. Furthermore, E. faeclais attenuates proinflammatory cytokines secretion through the suppression of JNK and p38 and also c-JUN signaling pathways. The inhibition of inflammatory responses by E. faecalis could bypass NF-kB signaling pathways. Cytokine receptors but TLRs may play the key role in the modulation of immune responses in IECs. This finding highlights new cellular targets and approaches for therapeutic treatment of inflammatory disease in human.
Appears in Collections:Ph.D Theses (Open)

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